Bacteria have developed an impressive ability to survive and propagate in highly diverse and changing environments by evolving phenotypic heterogeneity. Phenotypic heterogeneity ensures that a subpopulation is well prepared for environmental changes. The expression bet hedging is commonly (but often incorrectly) used by molecular biologists to describe any observed phenotypic heterogeneity. In evolutionary biology, however, bet hedging denotes a risk‐spreading strategy displayed by isogenic populations that evolved in unpredictably changing environments. Opposed to other survival strategies, bet hedging evolves because the (...) selection environment changes and favours different phenotypes at different times. Consequently, in bet hedging populations all phenotypes perform differently well at any time, depending on the selection pressures present. Moreover, bet hedging is the only strategy in which temporal variance of offspring numbers per individual is minimized. Our paper aims to provide a guide for the correct use of the term bet hedging in molecular biology. (shrink)

Business managers regularly employ metaphorical violent rhetoric as a means of motivating their employees to action. While it might be effective to this end, research on violent media suggests that violent rhetoric might have other, less desirable consequences. This study examines how the use of metaphorical violent rhetoric by business managers impacts the ethical decision making of employees. We develop and test a model that explains how the use of violent rhetoric impacts employees’ willingness to break ethical standards, depending on (...) the source of the rhetoric. The results of two experiments suggest that the use of violent rhetoric by a CEO at a competing company increases employees’ willingness to engage in ethical violations while the use of violent rhetoric by employees’ own CEO decreases their willingness to engage in unethical behavior. Furthermore, we find that participants who made less ethical decisions motivated by violent rhetoric used by a competitor’s CEO did not view their decisions as less ethical than the other participants in the experiments. The results of these studies highlight potentially harmful unintended consequences of the use of violent rhetoric, providing knowledge that should be useful to managers and academics who want to increase employee motivation without increasing a willingness to engage in unethical behavior. (shrink)

New Blackfriars, Volume 102, Issue 1101, Page 834-849, September 2021.

It is shown, assuming the linear case of Schinzel's Hypothesis, that the first-order theory of the structure $\langle \omega; +, P\rangle$ , where P is the set of primes, is undecidable and, in fact, that multiplication of natural numbers is first-order definable in this structure. In the other direction, it is shown, from the same hypothesis, that the monadic second-order theory of $\langle\omega; S, P\rangle$ is decidable, where S is the successor function. The latter result is proved using a general (...) result of A. L. Semenov on decidability of monadic theories, and a proof of Semenov's result is presented. (shrink)

Central to Thomas Sprat's History of the Royal Society was the description and justification of the method adopted and advocated by the Fellows of the Society, for it was thought that it was their method which distinguished them from ancients, dogmatists, sceptics, and contemporary natural philosophers such as Descartes. The Fellows saw themselves as furthering primarily a novel method, rather than a system, of philosophy, and the History gave expression to this corporate self-perception. However, the History's description of their method (...) was not necessarily accurate. Rather, as will be argued below, by a combination of subtle misrepresentation and selective exposition, Sprat portrayed a method which would further the aims of social and ecclesiastical stability and material prosperity, essential for the Royal Society since its continued existence depended upon the creation of a social basis for the institutionalized pursuit of natural philosophy. Some link had to be forged between the activities of the Society and the intellectual and social aspirations of the Restoration. To understand the intent and meaning of Sprat's History and the method there portrayed, we must therefore look to the institutional needs which it fulfilled. (shrink)

The reception of Buffon's Histoire Naturelle in the Enlightenment has not received the historical attention it deserves. Drawing primarily on archival sources, this paper examines Aberdeen reactions to the Histoire during the period c. 1750–1800. As pedagogues, the Aberdonians endeavoured to maintain intellectual orthodoxy, and hence they attacked Buffon for his apparent materialism and atheism. Moreover, the Aberdonians rejected Buffon's critique of taxonomy because they based their natural history courses on classifications of the three kingdoms of nature, and because they (...) attempted to use classification systems in nosology and the study of the human mind. Finally, in the 1790s Aberdeen readings of the Histoire were profoundly affected by the fears aroused by the French Revolution. (shrink)

BackgroundKinarm Standard Tests is a suite of upper limb tasks to assess sensory, motor, and cognitive functions, which produces granular performance data that reflect spatial and temporal aspects of behavior. We have previously used principal component analysis to reduce the dimensionality of multivariate data using the Kinarm End-Point Lab. Here, we performed PCA using data from the Kinarm Exoskeleton Lab, and determined agreement of PCA results across EP and EXO platforms in healthy participants. We additionally examined whether further dimensionality reduction (...) was possible by using PCA across behavioral tasks.MethodsHealthy participants were assessed using the Kinarm EXO and EP. Four behavioral tasks were performed that quantified arm sensory and motor function, including position sense [Arm Position Matching ] and three motor tasks [Visually Guided Reaching, Object Hit, and Object Hit and Avoid ]. The number of components to include per task was determined from scree plots and parallel analysis, and rotation type was decided on a per-task basis. To assess agreement, we compared principal components across platforms using distance correlation. We additionally considered inter-task interactions in EXO data by performing PCA across all six behavioral assessments.ResultsBy applying PCA on a per task basis to data collected using the EXO, the number of behavioral parameters were substantially reduced by 58–75% while accounting for 76–87% of the variance. These results compared well to the EP analysis, and we found good-to-excellent agreement values between PCs from the EXO and those from the EP. Finally, we were able to reduce the dimensionality of the EXO data across tasks down to 16 components out of a total of 76 behavioral parameters, which represents a reduction of 79% while accounting for 73% of the total variance.ConclusionPCA of Kinarm robotic assessment appears to capture similar relationships between kinematic features in healthy individuals and is agnostic to the robotic platform used for collection. Further work is needed to investigate the use of PCA-based data reduction for the characterization of neurological deficits in clinical populations. (shrink)

The only way to settle conclusively what any part of a language means is to discover the circumstances, both linguistic and non-linguistic, in which the speakers of the language are prepared to use it. This is not a new doctrine, but Wittgenstein gave it new life by dramatising the following question: If someone used an expression in a radically non-standard way, could anything he said about his state of mind convince us that he nevertheless meant it in a standard way? (...) To answer ‘No’ to this, and to generalize that answer, is to say that the last-resort criteria for what something means lie in the way in which it is used - a fairly plain statement which I shall call ‘the behavioural theory (of meaning)’ and with which I shall here have no quarrel at all. What I wish to do in the following pages is to consider the relationship between the behavioural theory and some aspects of the concept of proof. It is beyond dispute that one can be led, by one’s acceptance of certain premisses, to accept a certain conclusion. There is, though, a problem about the nature of this ‘leading’. On the one hand, it is usual to think of it as sometimes having the nature of a forcing: ‘If you say that, you are committed to admitting this also; you cannot accept the one and reject the other.’ On the other hand, the behavioural theory of meaning makes it difficult to see how there can possibly be such a relationship between the premisses and the conclusion of any proof. There are many ways of bringing out the apparent clash between the behavioural theory and the notion of logical forcing or committal. Perhaps the clearest of them arises from asking how there can be room for a concept of committal in a purely behavioural study. In this spirit, we might grant that our knowledge of some of the ways in which the parts of a language are used may lead us to expect to find certain sorts of further use and not others; and we could compare such expectations with those of an anthropologist who finds that a certain society has a matriarchal system of authority and then proceeds to investigate its inheritance laws.. (shrink)

The black hole information problem provides important clues for trying to piece together a quantum theory of gravity. Discussions on this topic have generally assumed that in a consistent theory of gravity and quantum mechanics, quantum theory is unmodified. In this review, we discuss the black hole information problem in the context of generalisations of quantum theory. In this preliminary exploration, we examine black holes in the setting of generalised probabilistic theories, in which quantum theory and classical probability theory are (...) special cases. We are able to calculate the time it takes information to escape a black hole, assuming that information is preserved. In quantum mechanics, information should escape pure state black holes after half the Hawking photons have been emitted, but we find that this get’s modified in generalisations of quantum mechanics. Likewise the black-hole mirror result of Hayden and Preskill, that information from entangled black holes can escape quickly, also get’s modified. We find that although information exits the black hole as predicted by quantum theory, it is fairly generic that it fails to appear outside the black hole at this point—something impossible in quantum theory due to the no-hiding theorem. The information is neither inside the black hole, nor outside it, but is delocalised. (shrink)

Gyula Klima’s distinctive work recovering medieval philosophy has inspired a generation of scholars. Klima’s attention to the distinctive terms, problems, and assumptions that constitute alternative historical conceptual frameworks has informed work in philosophy of language and logic, cognition and philosophical psychology, and metaphysics and theology. This volume celebrates Klima’s project by collecting new essays by colleagues, collaborators, and former students. Covering a wide range of thinkers (Plotinus, Anselm, Aquinas, Buridan, Ockham, and others) and various specifc questions (e.g., about language, cognition, (...) the soul, and God), it is unifed by a common interest in applying historically sensitive, hermeneutically sophisticated, and logically rigorous philosophical interpretation to recover, and appreciate, lost perspectives. (shrink)

Energy is a crucial concept within classical and quantum physics. An essential tool to quantify energy is the Hamiltonian. Here, we consider how to define a Hamiltonian in general probabilistic theories—a framework in which quantum theory is a special case. We list desiderata which the definition should meet. For 3-dimensional systems, we provide a fully-defined recipe which satisfies these desiderata. We discuss the higher dimensional case where some freedom of choice is left remaining. We apply the definition to example toy (...) theories, and discuss how the quantum notion of time evolution as a phase between energy eigenstates generalises to other theories. (shrink)

Although the University of Leeds has attained something of a reputation for the quality of its scholarship in the history of science, few historians are aware of the impressive collection of early scientific and medical books and manuscripts to be found in the University libraries. In order to make the library resources more widely known, we embarked on a systematic survey of the contents of the main historical collections. We wanted not only to give a general impression of the particular (...) strengths and distinctive features of each collection, but also to mention the interesting or rare copies of individual works to be found in them. We have, therefore, examined every book related to the history of science and medicine in the relevant collections, and in doing so we have uncovered a number of important items. For example, we have identified a book which was once in Newton's library, and a previously unrecorded copy of Joseph Black's chemical lectures. More generally, we had not suspected the true size and range of the Chaston Chapman Collection, which makes it a valuable resource for the history of alchemy and early chemistry; nor were we initially aware of the strength of the Historical Collection of the Medical and Dental Library. The wealth of the legacies to the Brotherton and Special Collections also impressed us. (shrink)